The Journal of Phytopharmacology, 2020;9(1):1-4 ;   DOI:10.31254/phyto.2020.9101

Research Article

Sedum sarmentosum Protects against Alcoholic Fatty Liver Disease in Mice

Dujuan Shi¹ , Yuruo Gong¹ , Xialing Huang¹ , Wei Kevin Zhang¹ , Hebin Tang¹ , Xiaojun Li¹

Dujuan Shi,Yuruo Gong,Xialing Huang,Wei Kevin Zhang,Hebin Tang,Xiaojun Li

1. Department of Pharmacology, School of Pharmaceutical Sciences, South-Central University for Nationalities, No. 182, Minyuan Road, Wuhan 430074, China

*Author to whom correspondence should be addressed.

Received: 5th January, 2020 / Accepted: 3rd February, 2020

Abstract

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Objective: This study was carried out to explore the protective effect of Sedum sarmentosum (SS) on alcoholic fatty liver disease (AFLD). Methods: We conducted an acute experiment in which female Kunming mice were given intragastric administration of alcohol to induce AFLD every 12 h, three times in total. Fresh SS were ground into homogenate for oral treatment, and the mice received ethanol and SS at the same time. The mice were sacrificed 4 h after the last alcohol administration, and serum and liver were collected for testing. We found that SS was effective and then carried out subsequent experiments. The dried SS was ground into powder and successively extracted by petroleum ether, ethyl acetate, methanol and water. The extracts of various polar solvents were used for treatment via intragastric administration. Results: The serum triglyceride levels in serum and liver were decreased with the administration of fresh SS. The methanol extract and water fractions had better therapeutic effect. Conclusion: Fresh SS can serve as an effective therapeutic of AFLD, and the high polar fractions were active.

Keywords

Sedum sarmentosum, alcoholic fatty liver disease, serum triglyceride.

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