The Journal of Phytopharmacology, 2020;9(6):449-452 ; DOI:10.31254/phyto.2020.9612
Evaluation of C. pareira L stem and T. peruviana (pers.) K. Schum leaf for estrogenic activity
Jhuma Samanta1 , Snehendu Bhattacharya2 , Avtar Chand Ran3
1. Sr. Scientist, DNA labs-A Centre of Applied Sciences, Dehradun-248001, Uttarakhand, India
2. Former Director, GNIT College of Pharmacy, Gr. Noida- 201306, Uttar Pradesh, India
3. Dean-Director, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
*Author to whom correspondence should be addressed.
Received: 25th November, 2020 / Accepted: 30th December, 2020
Context: Methanolic extract of C. pareira stem and T. peruviana leaves are capable of producing antifertility activity in female rat by increasing estrogen level and decreasing progesterone level. Aim: The aim of the present study is to C. pareira L stem and T. peruviana (Pers.) K. Schum leaf for estrogenic activity. Material and Method: Methanolic extract were made from C. pareira stem and T. peruviana leaves (after removal of cardiac glycoside) using cold maceration process. Extracts were tested for estrogenic activity on female immature rat (50-60 gm) at dose level of 250mg/kg. Obtained data were compared with control and standard (estrogen treated) group data. Statistical Analysis: Statistical analysis of all data was made with statistical packages (GraphPad Instat) and ANOVA followed by Dunnett’s ttest was used for statistical analysis. Result: Decrease in the absolute weight of the uterus and uterine weight to body weight ratio in CPS-Me and TPL-Me-G group treated were significant (p
Body weight, C. pareira stem, Estrogenic activity, T. peruviana leaves, Uterine weight.
HOW TO CITE THIS ARTICLE
Samanta J, Bhattacharya S, Ran AC. Evaluation of C. pareira L stem and T. peruviana (pers.) K. Schum leaf for estrogenic activity. J Phytopharmacol 2020; 9(6):449-452.
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