The Journal of Phytopharmacology, 2019;8(5):232-237 ; DOI:10.31254/phyto.2019.8505
Preliminary screening of anti-ulcerati ve colitis activity of aqueous leaf extract of Spondias mombin Linn. (Anacardiaceae) and the possible mechanisms of action in rats
Agbaje EO1 , Sabo FO1 , Ujomu T2
1. Department of Pharmacology, Therapeutics & Toxicology, College of Medicine, University of Lagos, Nigeria
2. Department of Pharmacology and Therapeutic, University of Ibadan, Oyo State, Nigeria
*Author to whom correspondence should be addressed.
Received: 6th August, 2019 / Published : 13th October, 2019
Spondias mombin L. (Anacardiaceae) commonly known as ‘yellow mombin’ is a multipurpose herb cultivated in parts of the Brazilian Northeast for its edible fruits, oil and leaves. The bark is used to carve figures and leaves and roots used as medicine. Efforts in this study were devoted to evaluating the effect of aqueous leaf extract of Spondias mombin Linn. on SMB sub-acute dosing in a rat model of acetic acidinduced ulcerative colitis and acetic-acid induced ulcerative colitis (curative) models. Three graded doses of the extract were administered orally (50, 100 and 200mg/kg) for the prophylactic model and 200mg/kg for the curative model. The involvement of endogenous nitric oxide, prostaglandins and potassium ion in the cytoprotective action of S. mombin L. was also investigated. The extract showed a significant (p
Spondias mombin, ulcerative colitis, extract, plant, inflammation.
HOW TO CITE THIS ARTICLE
Agbaje EO, Sabo FO, Ujomu T. Preliminary screening of anti-ulcerati ve colitis activity of aqueous leaf extract of Spondias mombin Linn. (Anacardiaceae) and the possible mechanisms of action in rats. J Phytopharmacol 2019; 8(5):232-237.
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