The Journal of Phytopharmacology, 2021;10(2):80-83 ; DOI:10.31254/phyto.2021.10202
In silico evaluation of phytocompounds from Indian medicinal plants for Canine Mammary Tumours
V Ramakrishnan1 , P Ravikumar2 , T Raja2 , K Vijayarani2 , A Arivuchelvan3 , M Parthiban4 , M Thangapandiyan5 , SP Preetha1
1. Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai – 600 007, Tamil Nadu, India
2. Bioinformatics Centre and ARIS Cell, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai – 600 007, Tamil Nadu, India
3. Department of Animal Husbandry Statistics and Computer Applications, Veterinary College and Research Institute, Namakkal – 637 002, Tamil Nadu, India
4. Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai – 600 007, Tamil Nadu, India
5. Department of Veterinary Pathology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai – 600 007, Tamil Nadu, India
*Author to whom correspondence should be addressed.
Received: 1st February, 2021 / Accepted: 19th February, 2021
Canine mammary tumours are among the most predominant neoplasms and happen all the more usually among unblemished females which are not spayed at an early age. The previous study carried out at Madras Veterinary College reported that out of the 14,326 clinical cases presented in an eight months study, 61 cases were mammary tumours. The current study was aimed to screen chemo preventive effect of phytocompounds of Indian medicinal plants for Canine mammary tumours. Mammaglobin-B was taken as a target protein and it was modeled using I-Tasser. Around 920 phytocompounds were collected from different Indian medicinal plants using Dr. Duke’s database. In which, after checking Lipinski Rule of five, 132 compounds were selected for this study. The 3D structure of all the phytocompounds were retrieved from PubChem database. Docking studies were done using Discovery Studio 4.0. From the results, the phytocompounds Homocapsaicin (Libdcok score: 102.27), Homodihydrocapsaicin (Libdcok score: 101.55) and Isositsirikine (Libdcok score: 99.19) showed the best Libdcok score. Hence, the present study was concluded that the phytocompounds Homocapsaicin and Homodihydrocapsaicin from Capsicum annuum and Isositsirikine from Catharanthus roseus had potential effect against Canine mammary tumours.
Canine mammary tumours, Mammaglobin-B, Phytocompounds, Capsicum annuum, Catharanthus roseus.
HOW TO CITE THIS ARTICLE
Ramakrishnan V, Ravikumar P, Raja T, Vijayarani K, Arivuchelvan A, Parthiban M, et al. In silico evaluation of phytocompounds from Indian medicinal plants for Canine Mammary Tumours. J Phytopharmacol 2021; 10(2):80-83.
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