The Journal of Phytopharmacology, 2017;6(2):73-77 ; DOI:10.31254/phyto.2017.6202
Toxicity evaluation and protective effect of Rhus longipes Engl. leaf extract in paracetamol induced oxidative stress in wister rats
Olubukola S.Olorunnisola1 , Adewale Adetutu1 , Abiodun O.Owoade1 , Babatunde T.Adesina2 , Peter Adegbola1
1. Department of Biochemistry, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
2. Department of Animal Science; College of Agricultural Sciences, Landmark University, Ipetu Road; Omu-Aran; Kwara State Nigeria
*Author to whom correspondence should be addressed.
Received: 25th March, 2017 / Accepted: 22nd May, 2017
Aim: Acute toxicity and protective effect of ethanol leaf extract of Rhus longipes Engl. against Paracetamol induced oxidative stress was investigated. The LD50 of the leaf extract was determined using up and down technique and the effect of 1/10th and 1/20th/ LD50 of the extract on antioxidants enzymes and non-enzymes were assessed in the serum and isolated liver of normal and Paracetamol intoxicated rats. Data obtained were analyzed by one-way analysis of variance (ANOVA) and Dunnett’s t-test was used as the test of significance. Values were considered significant at P value < 0.05. The results obtained indicated that LD50 of Rhus longipes Engl. leaf extract is greater than 5000 mg/kg /body weight. A significant (p
Oxidative stress, Acute toxicity, Paracetamol, Antioxidant enzymes.
HOW TO CITE THIS ARTICLE
Olorunnisola OS, Adetutu A, Owoade AO, Adesina BT, Adegbola P. Toxicity evaluation and protective effect of Rhus longipes Engl. leaf extract in paracetamol induced oxidative stress in wister rats. J Phytopharmacol 2017;6(2):73-77.
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