The Journal of Phytopharmacology, 2021;10(3):173-179 ; DOI:10.31254/phyto.2021.10305
Formulation and Evaluation of in vitro antidiabetic Polyherbal tablets form some traditional used Herbs
T. Sampath Kumar1 , P. Muthusamy1 , R. Radha1 , K. Ilango2
1. Department of Pharmacognosy, College of Pharmacy, Madras medical college, Chennai 600003, Tamil Nadu, India
2. Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur- 603203, Chengalpattu Dt, Tamil Nadu, India
*Author to whom correspondence should be addressed.
Received: 21st March, 2021 / Accepted: 19th April, 2021
The main objective of the project is to formulate and evaluate poly herbal anti diabetic tablet. Polyherbal antidiabetic formulation consists of six herbs viz., Nigella sativa (seed), Moringa oleifera (seed), Linum usitatissimum (seed), Trigonella foenum(seed), Cinnamum zeylanicum (bark) and Macrotyloma uniflorum (seed). Nine preliminary clumps of tablets were defined by fluctuating the organization off the excipient’s extents for phenomenal stream property. The mixed powder of each of the nine preliminary groups were investigated for its stream attributes like mass thickness, tapped thickness, compressibility file, Hausner's proportion and Angle of rest. Absolutely nine preliminaries of plan were completed utilizing various decisions of excipients thinking about various realities of assembling issues just as quality deformities as a top priority. Every one of the resultant plans were assessed for their stream property, consistency of filling, consistency of weight, dampness substance and breaking down time. The dried polyherbal remove was streamlined for its quality measures and its cluster consistency by making nine diverse preliminary clumps (Trial 1,2,3,4,5,6,7,8,9). The preliminaries were exposed to preformulation boundaries to affirm the consistency and quality. The outcome presumes that the preliminary 9 was amazing in all boundaries and the qualities were found inside as far as possible and it was utilized for detail Polyherbal Tablet. The developed polyherbal Phytochemical study showed the presence of flavonoids in this formulation flavonoids, tannins phenolic compounds are by using qualitative phytochemicals anaylsis. The poly herbal tablets and extracts are subjected in to HPTLC analysis estimation of Quercetin and rutin. This may be responsible for the potent anti-diabetic activity. The in vitro antidiabetic activity of tablets was evaluated by glucose uptake assay by using 3T3 Cell line. Further investigations are suggested for solidness concentrates in the detailed polyherbal tablet and furthermore clinical preliminaries need to act in future in Human Volunteers.
Glucose uptake assay, 3T3 L1 Cell line, Anti Diabetic Tablet, Quercetin, Rutin, HPTLC.
HOW TO CITE THIS ARTICLE
Kumar TS , Muthuraj S, Muthusamy P, Radha R, Ilango K. Formulation and Evaluation of in vitro antidiabetic Polyherbal tablets form some traditional used Herbs. J Phytopharmacol 2021 ; 10 ( 3):173 - 179 .
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