The Journal of Phytopharmacology, 2015;4(2):97-101 ; DOI:10.31254/phyto.2015.4207
Antiulcerogenic activity of Solenostemon monostachyus
Louis U. Amazu1 , Bassey S. Antia2 , Jude E. Okokon3
1. Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu Campus, Imo State, Nigeria
2. Department of Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
*Author to whom correspondence should be addressed.
Objective: Solenostemon monostachyus P. Beauv (family Lamiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer activity. Materials and Methods: The effects of extract of Solenostemon monostachyus (75 - 225 mg/kg) and fractions (Aqueous and chloroform, 150 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results: The effect of ethanol extract of S. monostachyus (75 – 225 mg/kg) and fractions on experimentally induced ulcer were studied in rats. The extract (75 – 225 mg/kg) inhibited ethanol, indomethacin and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p
Solenostemon monostachyus, Gastric protective, Antiulcer.
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