The Journal of Phytopharmacology, 2021;10(3):196-200 ; DOI:10.31254/phyto.2021.10309
Does 2’-hydroxygenistein inhibit the endometrial proliferation? A preliminary study
Sylvin Benjamin Ateba1 , Dieudonné Njamen2 , Liselotte Krenn3
1. Department of Biology of Animal Organisms, Faculty of Science, University of Douala, P.O. Box 24157 Douala, Cameroon
2. Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
3. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria
*Author to whom correspondence should be addressed.
Received: 21st April, 2021 / Accepted: 4th May, 2021
Isoflavones, due to their claimed or demonstrated beneficial biological activities, have attracted great interest and gained popularity among the public. On the risk of endometrial hyperplasia, conflicting findings for such compounds have been reported and genistein has been intensively studied. Studies also indicated that 2’-hydroxylation of isoflavones can lead to beneficial components with superior bioactivity compared to isoflavones lacking this substituent. Till now there is no study evaluating the effect of 2’-hydroxygenistein on endometrial hyperplasia in vivo. In line with this, a 3-day uterotrophic assay was carried out to evaluate the effect of 2’-hydroxygenistein on the uterus as its endometrial hyperplasia is of significant clinical concern. Daily subcutaneous administration of 2’-hydroxygenistein significantly (p ? 0.05) increased uterine wet weight at 2 and 8 mg/kg/day, while it reduced (p ? 0.05) uterine epithelial height at all tested doses. In contrast, no significant variation was observed on vaginal epithelial height. As global result, it appears that 2’-hydroxygenistein might exhibit anti-proliferative effects in the uterus, while having no effect on the vagina. However, this aspect needs to be further investigated.
2’-Hydroxygenistein, uterotrophic assay, endometrial proliferation.
HOW TO CITE THIS ARTICLE
Ateba SB, Njamen D, Krenn L. Does 2’-hydroxygenistein inhibit the endometrial proliferation? A preliminary study. J Phytopharmacol 2021; 10(3):196-200.
Creative Commons (CC) License-
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (http://creativecommons.org/licenses/by/4.0/).
Copyright
Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.