The Journal of Phytopharmacology 2024; 13(5):359-360 ; DOI:10.31254/phyto.2024.13503
Limonin as serotonin mimetic to protect from Alzheimer’s disease
1. Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
2. Maya Institute of Pharmacy, Hathras, Uttar Pradesh, India
*Author to whom correspondence should be addressed.
Received: 10th October, 2024 / Accepted: 20th October, 2024
Limonin (LM), a limonoid glycoside isolated from leaves, fruits, and seeds of citrus plants, belongs to the class of furanolactones [1]. Recently, LM has gained significant interest due to its multiple biological activities such as anti-inflammatory, antitumor, antimicrobial, and antifeedant activity. Lu et al. [2] demonstrated that pretreatment of LPS-induced microglial cells with LM substantially prohibited the formation of ROS and prevented the deposition of NO, PGE2, IL-1β, IL-6, and TNF-α [2]. Furthermore, LM significantly reduced the expressions of iNOS and COX-2 [3]. Their results indicated that LM inhibited inflammatory response through repressing the formation of ROS, accretion and discharge of cytokines, and activation of inflammatory mediators, suggesting its potential as a neuroprotective agent.
Limonin, Serotonin, Alzheimer disease
HOW TO CITE THIS ARTICLE
Mayank, Kumar Y. Limonin as serotonin mimetic to protect from Alzheimer’s disease. J Phytopharmacol 2024; 13(5):359-360. doi: 10.31254/phyto.2024.13503
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