The Journal of Phytopharmacology, 2020;9(3):164-168 DOI:10.31254/phyto.2020.9302

Research Article

Terminalia catappa flour extract mitigated monosodium glutamate intoxicated rats’ kidney biofunction and histology

Philemon C Anuforo¹ , Anthony Cemaluk C Egbuonu¹ , Elizabeth U Egu²

Philemon C Anuforo,Anthony Cemaluk C Egbuonu,Elizabeth U Egu

1. Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Umuahia Abia State, Nigeria
2. Department of Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Umuahia Abia State, Nigeria

*Author to whom correspondence should be addressed.

Received: 16th April, 2020 / Accepted: 18th May, 2020

Abstract

Objective: This study investigated the Terminalia Catappa flour mitigated monosodium glutamate intoxicated rats’ kidney biofunction and histology. Materials and Methods: Twenty-four (24) male albino Wistar rats with mean weight of 120.61±15.15 g were divided into six groups (n=4). Group 1, the normal control group (received distilled water), group II, the negative control (received 8mg MSG/g b.wt), group III, the extract control (received 300 mg extract/kg b.wt), group IV (received 8 mg MSG/g b.wt. + 100 mg extract/kg b.wt.), group V (received 8 mg MSG/g b.wt. + 300 mg kg-1 b.wt. extract) and group VI received 8 mg MSG/g b.wt. + 500 mg extract/kg b.wt). Treatment was administered daily by oral gavage for 14 days. Data were subjected to one-way ANOVA followed by Duncan post-hoc test at p0.05) lower compared to all other groups. There was significant difference (p