ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology, 2019;8(3):91-95 DOI:10.31254/phyto.2019.8302

Research Article

Endothelium-dependent and independent effect of Guibourtia tessmannii (Caesalpiniaceae) on vascular contractility of rat

Koumba Madingou Noreen Orianna1,2 , Aworet Samseny Reine Raissa1 , Souza Alain3 , Sababenedyo Traore Alfred2

1. Laboratory of Pharmacology and Toxicology, Pharmacopoeia and Traditional Medicines Insti-tute, BP 1935 Libreville, Gabon.
2. Research Center in Biological, Food and Nutritional Sciences, University of Ouagadougou, 03 BP 7129 Ouagadougou, Burkina Faso.
3. Department of Biology, Faculty of Sciences, University of Sciences and Technique of Ma-suku (USTM), BP 941 Franceville, Gabon

*Author to whom correspondence should be addressed.

Received: 4th June, 2019 / Accepted: 8th May, 2019

Abstract


The stem barks of Guibourtia tessmannii (Caesalpiniaceae) are used in traditional Gabonese medicine as antihypertensive remedies. In the present study, we investigated vasorelaxant properties effect of aqueous extract from G. tessmannii and fuller understanding these mechanisms of action in vitro. The activity of Guibourtia tessmannii was evaluated on isolated aorta rings of rat constricted with KCl (80 mM) and norepinephrine (10-4 M). Cumulative concentrations (1 mg/mL - 100 mg/ml) of G. tessmannii provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl (95.69 ± 0.6% and 91.34 ± 4.90%, respectively). The vasorelaxant effect induced by G. tessmannii on the aorta precontracted by KCl was significant decreased in presence of N?-nitro-L-arginine methyl ester (11.30 ± 4.3 %, p

Keywords


aqueous extract, G. tessmannii, aorta, endothelium, vasorelaxation.

HOW TO CITE THIS ARTICLE

Orianna KMN, Raissa ASR, Alain S, Alfred SBT. Endothelium -dependent and independent effect of Guibourtia tessmannii (Caesalpiniaceae) on vascular contractility of rat . J Phytopharmacol 201 9 ; 8 ( 3): 9 1 -95 .

Creative Commons (CC) License-

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (http://creativecommons.org/licenses/by/4.0/).

Copyright

Copyright © 2019 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

Technical Support

×