The Journal of Phytopharmacology, 2018;7(1):25-28 DOI:10.31254/phyto.2018.7106

Research Article

Phytochemical screening and anticonvulsant activity of Sargassum ilicifolium (brown algae) in mice

Subhash R. Yende¹ , Uday N. Harle² , Sumit K. Arora³ , Vipinchandra B. Pande¹

Subhash R. Yende,Uday N. Harle,Sumit K. Arora,Vipinchandra B. Pande

1. Department of Pharmacology, Gurunanak College of Pharmacy, Nari, Nagpur, Maharashtra-440026, India
2. Clinical Research Consultant, Mahalaxmi Nagar, Nagpur, Maharashtra-440026, India
3. Department of Pharmacognosy, Gurunanak College of Pharmacy, Nari, Nagpur, Maharashtra-440026, India

*Author to whom correspondence should be addressed.

Received: 5th November, 2017 / Accepted: 21st December, 2017

Abstract

Sargassum ilicifolium (SI) is a tropical and subtropical marine macroalgae (brown algae) found in coastal area of India. Thais study investigated the anticonvulsant activity of SI in maximal electroshock (MES) induced convulsion and pentylenetetrazole (PTZ) induced convulsion in mice. The result of present study indicated that chloroform extract (600 mg/kg) and ethanol extract (400 mg/kg and 600 mg/kg) of SI significantly decreased the duration of tonic hind limb extension in MES model, as well as it significantly increased the latency to onset of convulsions in PTZ model. These results were comparatively similar with the effect of phenytoin (25 mg/kg) and phenobarbitone (20 mg/kg). This activity may be due to the presence of alkaloids, terpenoids, flavonoids, steroids and saponin in chloroform and ethanol extract of Sargassum ilicifolium. However, further research will be necessary to investigate the exact mechanism underlying this anticonvulsant activity.