The Journal of Phytopharmacology, 2018;7(3):292-297 DOI:10.31254/phyto.2018.7311

Research Article

Lipid-lowering effect of Vernonia amygdalina leaf extracts on Triton WR 1339 – induced hyperlipidaemia in the rats

Omede A¹ , Atanu FO¹ , Suleiman MS¹ , Omotoso OD¹ , Jegede R¹ , Sheneni VD¹

Omede A,Atanu FO,Suleiman MS,Omotoso OD,Jegede R,Sheneni VD

1. Department of Biochemistry, Kogi State University, PMB 1008, Anyigba, Nigeria

*Author to whom correspondence should be addressed.

Received: 11th April, 2018 / Accepted: 26th May, 2018

Abstract

Vernonia amygdalina is a common plant reported to have several health benefits. This study investigated the dose dependent hypolipidemic potentials of the leaf extracts, following Triton WR 1339 induced hyperlipidemia. Adult male albino rats (average weight 185 ± 0.7 g) were pretreated with the ethyl acetate extract at 0, 100, 200 and 400 mg/kg body weight for seven (7) days after which the hyperlipidemia was induced with Triton WR 1339 (200 mg/kg body weight). The serum and liver of the animals were then assayed for; total cholesterol, triglycerides, HDL (high density lipoprotein) and LDL (low density lipoprotein). Histopathological investigation was carried out in the liver of all experimental animals. The result showed that pretreatment with ethyl acetate extract of V. amygdalina elicited a significant dose dependent (P