The Journal of Phytopharmacology, 2017;6(1):20-26 DOI:10.31254/phyto.2017.6103
Anti-allergy potential and possible modes of action of Sphenocentrum jollyanum pierre fruit extracts
Olorunnisola O.S1 , Adetutu A1 , Fadahunsi O.S1
1. Biochemistry Department, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
*Author to whom correspondence should be addressed.
Received: 5th February, 2017 / Accepted: 5th March, 2017
Sphenocentrum jollyanum (SJ) is widely used traditionally in the management of various ailments. Information on its anti-allergy property and possible modes of action is scanty in the literature. Thus, this study was aimed at evaluating the anti-allergic potential of crude and secondary metabolites (Tannins, Saponins, Flavonoids and Alkaloids) of S.J fruit extracts. Aqueous, ethanol extracts and the secondary metabolites were extracted using standard techniques. Inhibitory effect of the extracts on erythrocytes membrane stabilization, trypsin and lipoxygenase (in vitro) were used to assess anti-inflammatory properties, while extract with the most potent anti-inflammatory activity was used to assess the anti-allergy property of the fruit in milk induced eosinophilia and leukocytosis mice. Result of the study revealed that the aqueous extract has highest percentage yield (38.00g), while saponins (10.20%), alkaloids (8.51%) and tannins (6.70%) are the predominant phytochemicals. The ethanol extract of the fruit demonstrated significant (p
Anti-Allergy, Anti-Inflammation, Sphenocentrum jollyanum, Fruit, Phytochemicals.
HOW TO CITE THIS ARTICLE
Olorunnisola OS, Adetutu A, Fadahunsi OS. Anti-allergy potential and possible modes of action of Sphenocentrum jollyanum pierre fruit extracts. J Phytopharmacol 2017;6(1):20-26.
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