The Journal of Phytopharmacology, 2014;3(3):204-213 DOI:10.31254/phyto.2014.3308
Psychopharmacological studies of Mammea africana stem bark extract
Jude E. Okokon1 , Koofreh Davies2
1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
2. Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
*Author to whom correspondence should be addressed.
Herbal medicine is an integral part of the health care system in most developed and developing countries of the world. Objective: The stem bark of Mammea africana used traditionally in the treatment of mental disorders was evaluated for depressive effect on the central nervous system (CNS). Materials and Method: The stem bark extract was investigated for depressive activity in the open field, force swimming and tail suspension tests as well as its anticonvulsant potential against pentylene tetrazol and aminophylline-induced convulsions. The effect of the extract on phenobarbitone induced sleeping time was also evaluated. Results: The extract was found to significantly (p
Mammea africana, Depressant, Sedation, Anticonvulsant, Convulsion.
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