The Journal of Phytopharmacology, 2016;5(4):150-156 DOI:10.31254/phyto.2016.5406
Antidiabetic potentials of Syzygium guineense methanol leaf extract
Ifeoma Chinwude Ezenyi1 , Oluchi Nneka Mbamalu2 , Lucy Balogun1 , Liberty Omorogbe1 , Fidelis Solomon Ameh1 , Oluwakanyinsola Adeola Salawu1
1. Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
2. School of Pharmacy, University of the Western Cape, Bellville, South Africa
*Author to whom correspondence should be addressed.
This study examines the effects of a methanol extract of Syzygium guineense leaves in streptozotocin (STZ) - induced diabetes, evaluates its effect on alpha glucosidase and 2, 2-diphenyl-1-picrylhydrazyl radical. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (60 mg/kg). An oral glucose tolerance test was performed after diabetes induction and repeated after 14 days of treatment with the extract. The extract elicited antihyperglycemic action in diabetic rats evidenced by an improved oral glucose tolerance. A dose of 250 mg/kg of extract significantly (P
Alpha glucosidase, Antioxidant, Syzygium guineense.
HOW TO CITE THIS ARTICLE
Ezenyi IC, Mbamalu ON, Balogun L, Omorogbe L, Ameh FS, Salawu OA. Antidiabetic potentials of Syzygium guineense methanol leaf extract. J Phytopharmacol 2016;5(4):150-156.
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