The Journal of Phytopharmacology 2024; 13(5):359-360 DOI:10.31254/phyto.2024.13503

Letter to Editor

Limonin as serotonin mimetic to protect from Alzheimer’s disease

Mayank¹ , Yogesh Kumar²

Mayank,Yogesh Kumar

1. Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
2. Maya Institute of Pharmacy, Hathras, Uttar Pradesh, India

*Author to whom correspondence should be addressed.

Received: 10th October, 2024 / Accepted: 20th October, 2024

Abstract

Limonin (LM), a limonoid glycoside isolated from leaves, fruits, and seeds of citrus plants, belongs to the class of furanolactones ^[1]. Recently, LM has gained significant interest due to its multiple biological activities such as anti-inflammatory, antitumor, antimicrobial, and antifeedant activity. Lu et al. ^[2] demonstrated that pretreatment of LPS-induced microglial cells with LM substantially prohibited the formation of ROS and prevented the deposition of NO, PGE2, IL-1β, IL-6, and TNF-α ^[2]. Furthermore, LM significantly reduced the expressions of iNOS and COX-2 ^[3]. Their results indicated that LM inhibited inflammatory response through repressing the formation of ROS, accretion and discharge of cytokines, and activation of inflammatory mediators, suggesting its potential as a neuroprotective agent.