The Journal of Phytopharmacology 2023; 12(1):27-31 ; DOI:10.31254/phyto.2023.12104
Protective effect of Spirulina platensis extract on aflatoxin B1 immunotoxicities in mice
Masese Johnson1 , Kipkoech Gilbert2 , Mwitari Peter3 , Nguka Gordon4 , Mutai Charles5 , Kimoloi Sammy6
1. School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, P.O Box 190 – 50100, Kakamega Kenya
2. Department of Biochemistry, Biotechnology, Kenyatta University P.O Box 43844 - 00100, Nairobi, Kenya
3. Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), P.O. Box 54840 - 00200, Nairobi, Kenya
4. Department of Nutritions and diatetics, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega, Kenya
5. Department of Medical Laboratory Sciences, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega Kenya.
6. Department of Medical Laboratory Sciences, School of Public Health, Biomedical Sciences and Technology, Masinde Muliro University of Science & Technology P.O Box 190 – 50100, Kakamega.
*Author to whom correspondence should be addressed.
Received: 8th January, 2023 / Accepted: 22nd February, 2023
Aspergillus ?avus and Aspergillus parasiticus are the main Aspergillums species that form aflatoxins. Aflatoxins are hepatotoxic, teratogenic, carcinogenic and immunosuppressive. This study aimed to assess Spirulina platensis (S. platensis) extract inhibitory effect against aflatoxin B1 (AFB1) induced immunotoxicity in male Swiss albino mice. Twenty-five inbred weaned mice were randomly divided into five groups. Group I (Control group), were given routine diet. Treatments administered were: Group II (S. platensis extract 100 mg/kg/day), Group III (AFB1 200 µg/kg/day), Group IV (S. platensis extract 100 mg/kg/day and AFB1 200 µg/kg/day) and Group V (S. platensis extract 200 mg/kg/day and AFB1 200 µg/kg/day) for 28 consecutive days. Blood was aseptically collected and centrifuged to obtain serum. Quantitative determination of IgG, IgM and IgA in blood serum was done using ELIZA kits. One-way ANOVA data analysis was done. Post-hoc analysis was done using Tukey’s Honestly Significantly Differenced (HSD). P
Spirulina platensis, Aflatoxin B1, Immune changes, Protective effects
HOW TO CITE THIS ARTICLE
Johnson M, Gilbert K, Sammy K, Peter M, Gordon N, Charles M.Protective effect of Spirulina platensis extract on aflatoxin B1immunotoxicities in mice. J Phytopharmacol 2023; 12(1):27-31. doi:10.31254/phyto.2023.12104
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