The Journal of Phytopharmacology, 2020;9(3):175-177 ; DOI:10.31254/phyto.2020.9304
Evaluation of Hepatoprotective activity of Moringa oleifera in chicken
V. Ranganathan1 , N. Punniamurthy2 , D. Basheer Ahamad3 , S. Sathesh Kumar4
1. Professor and Head, Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu, Thanjavur-614 625, Tamil Nadu, India
2. Professor (Retired), Tamil Nadu Veterinary and Animal Sciences University, Tamil Nadu, India
3. Professor, Department of Veterinary Pathology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Tirunelveli – 627358, Tamil Nadu, India
4. Professor and Head, Department of Veterinary Gynaecology and Obstetrics, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Tirunelveli – 627358, Tamil Nadu
*Author to whom correspondence should be addressed.
Received: 26th March, 2020 / Accepted: 23rd May, 2020
The present study was carried out to evaluate the hepatoprotective activity of Moringa oleifera on paracetamol induced hepatotoxicity in chicken. Twenty-four Giriraja birds were divided into four groups with six birds in each group. Birds in group I served as control and was administered with distilled water for 23 days continuously. Birds of group II were given paracetamol @ 2 g/kg body weight orally on day 17 and continued till the end of the experiment. Birds in group III were given silyamin @ 100mg/kg for 16 days and paracetamol was given from 17th day onwards @ 2 g/kg body weight along with silymarin till the end of the experiment. Birds in group IV were given shade dried powdered leaves of Moringa oleifera @ 1000 ppm in feed for 16 days and paracetamol was given from 17th day onwards @ 2 g/kg body weight along with medicinal plant till the end of the experiment. The biomarker enzymes such as alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase were tested and expression of mRNA levels of proinflammatory cytokines were screened for hepatoprotective activity of the plant. Histopathological observations were made with liver tissue for analysing hepatoprotective activity of the plant. Based on the results, the study suggests that Moringa oleifera has the potential to act as hepatoprotective agent.
Moringa oleifera, Chicken, Paracetamol, Real Time PCR.
HOW TO CITE THIS ARTICLE
Ranganathan V, Punniamurthy N, Ahamad DB, Kumar SS. Evaluation of Hepatoprotective activity of Moringa oleifera in chicken. J Phytopharmacol 2020; 9(3):175-177.
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