The Journal of Phytopharmacology, 2019;8(2):52-56 ; DOI:10.31254/phyto.2019.8205
Antiplasmodial and antimicrobial potential of Canthium subcordatum extracts and isolates
Awantu AF1,2,3 , Fotsing FYS4,3 , Bankeu KJJ1,3 , Lenta NB5 , Tsouh FPV6 , Boyom FF6 , Assob NJC7 , Tsamo E3 , Sewald N2
1. Department of Chemistry, Faculty of Science, The University of Bamenda, P.O Box 39, Bambili, Cameroon
2. Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O Box 100131, 33501 Bielefeld, Germany
3. Department of Organic Chemistry, Faculty of Science, TWAS research Unit (TRU) of the University of Yaoundé 1, P.O Box 812, Yaoundé, Cameroon
4. Department of Chemistry, Higher Teachers’ Training College, University of Maroua, P.O Box 55, Maroua, Cameroon
5. Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé 1, P.O Box 47, Yaoundé, Cameroon
6. Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O Box 812, Yaoundé, Cameroon
7. Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, P.O Box 12, Buea, Cameroon
*Author to whom correspondence should be addressed.
Received: 7th February, 2019 / Published : 20th April, 2019
Phytochemical studies on the stem bark of Canthium subcordatum afforded eight known compounds: ?sitosterol (1), ursolic acid (2), cerbinal (3), quinovic acid (4), Cerberinic acid (5), 3-O-?-Dglucopyranosylquinovic acid (6), 3-O-?-D-glucopyranosyloleanolic acid (7) and Clemahexapetoside B (8). Interestingly, 3, 5 and 8 were isolated and characterized for the first time from the genus Canthium. Their structures were elucidated using their physical and spectroscopic data. Furthermore, antiplasmodial potency of Canthium subcordatum and antimicrobial activities of 6, 5 and 8 has not yet been investigated. Fractions and isolates were tested for their antiplasmodial potency. Only the methanol fraction inhibited the growth of P. falciparum with an IC50 value of 3.044 µg/mL. The isolates were also tested against eight bacteria and fungi strains. 4 and 5 were the most active with inhibition diameter zones equal or above 12 mm and MIC equal or lower than 39 µg/mL.
Canthium subcordatum; Rubiaceae; antiplasmodial; antimicrobial activity, macrocyclic glycoside.
HOW TO CITE THIS ARTICLE
Awantu AF, Fotsing FYS, Bankeu KJJ, Lenta NB, Tsouh FPV, Boyom FF, et al. Antiplasmodial and antimicrobial potential of Canthium subcordatum extracts and isolates. J Phytopharmacol 2019; 8(2):52-56.
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