The Journal of Phytopharmacology, 2018;7(2):180-184 ; DOI:10.31254/phyto.2018.7213
Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice
Nitin G Dumore1 , Milind J Umekar1 , Brijrsh G Taksande1 , Manish M Aglawe1
1. Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar, College of Pharmacy, New Kamptee, Nagpur (M.S.), 441 002, India
*Author to whom correspondence should be addressed.
Received: 17th January, 2018 / Accepted: 2nd March, 2018
Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss albino mice nicotine mediated locomotor sensitization and anxiogenic effects of chronic and acute nicotine treatment respectively was tested per se or in combination with WSE. In addition, nicotine withdrawal induced anxiety-like behavior was also studied. Locomotor sensitization was tested by employing open field test (OFT), while symptoms of anxiety were evaluated by subjecting mice to elevated plus maze (EPM). Results: Daily treatment with nicotine (subcutaneous) for 7 days showed gradual increase in the locomotor activity in OFT as compared to saline group indicating the development of locomotor sensitization. Following 3 days of drug free period, nicotine challenge on day 11 also showed rise in locomotor activity depicting expression of sensitization. WSE pretreatment inhibited the nicotine induced development and expression of locomotor sensitization. WSE+nicotine treated group showed decreased ambulations as compared to per se nicotine group on day 1-7 and day 8 (P
Withania Somnifera, Nicotine, Locomotor sensitization, Anxiety.
HOW TO CITE THIS ARTICLE
Dumore NG, Umekar MJ, Taksande BG, Aglawe MM. Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice. J Phytopharmacol 2018; 7(2):180-184.
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