The Journal of Phytopharmacology, 2018;7(3):270-274 ; DOI:10.31254/phyto.2018.7307
Madhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy
Chandrakant V. Thakare1 , Chandrashekhar D. Upasani2
1. School of Pharmacy, Swami Ramanand Teerth Marathwada University, Dist. Nanded, Maharashtra, India
2. Department of Pharmacology, Shriman Sureshdada Jain College of Pharmacy, Chandwad Dist. Nashik, Maharashtra, India
*Author to whom correspondence should be addressed.
Received: 27th March, 2018 / Accepted: 11th May, 2018
Objective: Present study was designed to screen the antiepileptic property of aqueous extract of Madhucalongifolia (AqML) in laboratory animals. Materials and methods: Rat and mice were divided in different groups. Antiepileptic activity was tested by using maximal electric shock (MES), Pentylenetertrazole (PTZ) and lithium pilocarpine (Li-Pilocarpine) models. Treatment group of animals were received AqML at 100, 200 and 400 mg/kg p.o. for 7 days. At the end of treatment period, different parameters related of antiepileptic action were observed. Result: Preliminary phytochemical investigation revealed the presence of carbohydrate, protein, amino acid and alkaloids. Animals treatment with AqML showed significant (p
Antiepileptic, PTZ, Lithium-pilocarpine.
HOW TO CITE THIS ARTICLE
Thakare CV, Upasani CD. Madhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy. J Phytopharmacol 2018; 7(3):270-274
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