The Journal of Phytopharmacology, 2018;7(3):325-333 ; DOI:10.31254/phyto.2018.7316
Antipyretic effect of a polyherbal ayurvedic formulation: A randomized controlled clinical study
Amit K Taraphdar1 , Arup Mukherjee2 , Mradu Gupta1
1. Department of Dravyaguna, Institute of Post Graduate Ayurvedic Education & Research, 294/3/1, Acharya Prafulla Chandra Road, Kolkata, West Bengal - 700 009, India
2. Department of Chemical Technology, University College of Technology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, West Bengal - 700 009, India
*Author to whom correspondence should be addressed.
Received: 14th April, 2018 / Accepted: 28th May, 2018
The ancient ayurvedic text A????gah?daya of V?gbha?a (7th Century A.D.) prescribes a specific formulation of four plants having antipyretic properties with minimal side-effects. This polyherbal ayurvedic formulation contains whole plant of Solanum surratense, rhizomes of Zingiber officinale, stem of Tinospora cordifolia and fruits with bracts of Piper longum, exhibited significant antipyretic-analgesic properties during rodent experiments without any toxicity may be due to flavonoidic phenolic compounds in it. Present randomized controlled clinical study in sixty eight patients was conducted with this polyherbal ayurvedic formulation using aspirin as standard drug for comparison. The primary outcome measured was reduction in body temperature, while the secondary outcomes measured were assessment of associated symptoms of fever and routine haematological parameters. A representative sample of patients was also studied for reduction in the level of prostaglandin (PGE2). The clinical study showed that fever was rapidly and substantially reduced after oral administration of the test drug and this antipyretic effect was significant (p
Ayurveda, Antipyretic, Solanum surratense, Zingiber officinale, Tinospora cordifolia, Piper longum
HOW TO CITE THIS ARTICLE
Taraphdar AK, Mukherjee A, Gupta M. Antipyretic effect of a polyherbal ayurvedic formulation: A randomized controlled clinical study. J Phytopharmacol 2018; 7(3):325-333.
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