The Journal of Phytopharmacology, 2018;7(4):366-372 ;   DOI:10.31254/phyto.2018.7403

Research Article

Acute and subacute toxicity of the aqueous extract of Amaranthus viridis (Amaranthaceae) leaves in rats

Affy Mataphouet Emmanuel¹ , Kouakou Koffi Roger¹ , Douhoure Gnaore Toussaint² , Kouakou Koffi¹

Affy Mataphouet Emmanuel,Kouakou Koffi Roger,Douhoure Gnaore Toussaint,Kouakou Koffi

1. Laboratoire d’Endocrinologie et Biologie de la Reproduction, UFR Biosciences, Université Félix Houphouët Boigny, Abidjan, Côte d’Ivoire, 22 BP 582 Abidjan 22.
2. Laboratoire de Chimie des Substances Naturelles, UFR Sciences de la Structure de la Matière et Technologie, Université Félix Houphouët Boigny, Abidjan, Côte d’Ivoire, 22 BP 582 Abidjan 22.

*Author to whom correspondence should be addressed.

Received: 14th May, 2018 / Accepted: 5th July, 2018

Abstract

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Amaranthus viridis is a plant of the family Amaranthaceae, used by traditional medicine in the treatment of several diseases. The aim of this study was to evaluate the toxicological activities of A. viridis. To assess these activities, two types of test were performed: Acute and subacute toxicity test. Phytochemical analysis performed on the aqueous extract of A. viridis revealed the presence of polyphenol, flavonoids, tannins, sterolpolyterpenes, Saponosids, cardiac glycosides, traces of alkaloids and leucoanthocyanines. The aqueous extract of Amaranthus viridis showed no evidence of single dose toxicity (2000 mg/kg) when studying acute toxicity. The subacute toxicity study of the aqueous extract of A. viridis at doses of 200, 400 and 600 mg/kg showed no signs of toxicity on biochemical, hematological or histological parameters. The results showed that A. viridis does not cause toxicity at the doses studied.

Keywords

Amaranthus viridis, toxicity, Histopathology examination.

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