The Journal of Phytopharmacology, 2018;7(4):373-375 ; DOI:10.31254/phyto.2018.7404
Evaluation of anticonvulsant activity of ethanolic extract of Gomphrena serrata by using Swiss albino mice
Joji Babu V1 , Sireesha TSM1 , Anjana Male Ch. KVLSN1 , Swathi V1 , Balaiah S1 , Subba Reddy D1
1. Department of Pharmacology, Nirmala College of Pharmacy, Atmakuru (v), Mangalagiri(M), Guntur-522503, Andhra Pradesh, India
*Author to whom correspondence should be addressed.
Received: 21st April, 2018 / Accepted: 12th July, 2018
Epilepsy is characterised by abnormal behaviour which is leading to tonic flexon, tonic extension, clonus and stupor. Many novel therapeutic regimens were used to treat these disorders through different ways including altering neurotransmission, but so far there is no specific treatment approach which is satisfactory to the patients in terms of complete cure. Our approach is to make understand the herbal medicines usage towards epilepsy. The ethanolic plant extract of Gomphrena Serrata at 400mg/kg, 600mg/kg and 800mg/kg were given to albino mice which were treated with maximum electric shock of 30mA current and pentelene tetrazolium in two different techniques. The results with these extract doses showed significant results which indicated decrease in clonic extension and stupor. Whereas there is no decrease in the tonic flexon observed with all doses. All these results were compared with the standard drug Phenytoin at 25mg/kg I.P. However, the ethanolic plant extract of Gomphrena Serrata at 600mg/kg showed marked increase in the therapeutic activity which is equivalent to Phenytoin and can be compared. Apart from these the ethanolic plant extract of Gomphrena Serrata at 400mg/kg, 600mg/kg and 800mg/kg showed significant decrease in the recovery times when compared to control group.
Convulsions, tonic flexon, clonic extension, stupor, Gomphrena Serrata and Phenytoin.
HOW TO CITE THIS ARTICLE
Babu V J, Sireesha TSM, Anjana Male Ch. KVLSN, Swathi V, Balaiah S, Reddy D S . Evaluation of anticonvulsant activity of ethanolic extract of Gomphrena serrata by using Swiss albino mice . J Phytopharmacol 201 8 ; 7 ( 4):373 -375 .
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