The Journal of Phytopharmacology, 2021;10(2):84-88 ; DOI:10.31254/phyto.2021.10203
In vivo antiplasmodial evaluation of methanol mesocarp extract of Citrillus lanatus in Plasmodium berghei berghei infected mice.
Ettebong EO1 , Inyang GB2 , Bassey AIL1 , Udobang JA1 , Thomas PS3 , Essien EG2 , Ubulom PE4 , Obot DN1
1. Department of Clinical Pharmacology and Therapeutics, University of Uyo, Uyo, Nigeria
2. Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria
3. Department of Pharmacognosy and Natural Medicine, University, Uyo, Uyo, Nigeria
4. Department of Animal and Environmental Biology, Faculty of Science, University of Uyo, Nigeria
*Author to whom correspondence should be addressed.
Received: 3rd October, 2020 / Accepted: 16th January, 2021
Aim: The aim of this study was to evaluate the in vivo antiplasmodial activities of the methanol mesocarp extract of Citrillus lanatus in mice infected with Plasmodium berghei berghei. Materials and Methods: The extract (125, 250, and 500 mg/kg) was administered orally to mice and were assessed in suppressive, repository and curative tests using Chloroquine (5 mg/kg) and Pyrimethamine (1.2 mg/kg) as positive controls. Results: A dose-dependent, significant (p < 0.001) antiplasmodial effect was recorded in the suppressive test relative to control. The extract also demonstrated a dose-dependent, significant (p < 0.01 – 0.001) prophylactic and curative effects when compared to the controls. These antiplasmodial effects of the extract compared favourably with those of the standard drugs. The extract in addition, increased the mean survival times of the infected mice. Conclusions: The methanol mesocarp extract of C. lanatus possesses antiplasmodial activities, thereby corroborating its use in natural medicine in the treatment of malaria.
Citrillus lanatus, antiplasmodial, Plasmodium berghei berghei, extract, mice.
HOW TO CITE THIS ARTICLE
Ettebong EO, Inyang GB, Bassey AIL, Udobang JA, Thomas PS, Essien EG, et al. In vivo antiplasmodial evaluation of methanol mesocarp extract of Citrillus lanatus in Plasmodium berghei berghei infected mice. J Phytopharmacol 2021; 10(2):84-88.
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