The Journal of Phytopharmacology, 2017;6(4):205-209 ; DOI:10.31254/phyto.2017.6401
Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats
Emmanuel Onuka Agbai1 , Chisomaga Chiwuikem Eke2 , Collins Okechukwu Nwanegwo2 , Ugochukwu Bond Anyaehie3
1. Department of Human Physiology, School of Basic Medical Sciences, Federal University of Technology, PMB 1526 Owerri, Imo State, Nigeria
2. Department of Prosthetics and Orthotics, School of Health Technology, Federal University of Technology, PMB 1526 Owerri, Imo State, Nigeria
3. Department of Physiology, College of Medicine, Imo State University Owerri, Imo State, Nigeria
*Author to whom correspondence should be addressed.
Received: 6th June, 2017 / Accepted: 25th August, 2017
The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in female rats irrespective of the estrous cycle. The animals were randomly assigned to four groups (n = 7): group A (control), Group B, 180 mg-kg of ibuprofen, Group C, 200 mg-kg of Piper guineense extract, Group D, 180 mg-kg of ibuprofen and 200 mg-kg of Piper guineense extract. At the end of two weeks administration, rats were sacrificed under urethane anesthesia and hormones measured using enzyme-linked immunosorbent assay method. Results showed significant reduction in serum follicle-stimulating hormone and luteinizing hormone following ibuprofen administration in Group B rats at P < 0.05. Piper guineense extract treated Group C rats caused significant reduction in serum luteinizing hormone and progesterone at P < 0.05. In contrast, serum follicle stimulating hormone significantly increased in Group D rats at P < 0.05 whereas serum luteinizing hormone and progesterone were markedly reduced at P < 0.05. Serum estrogen level remained unchanged among groups. In conclusion, results obtained suggested that extract inhibited luteinization of follicles thus could impair ovulation, therefore the extract can be used as oral contraceptive in family planning.
estrogen, follicle-stimulating hormone, ibuprofen, luteinizing hormone, Piper guineense, progesterone.
HOW TO CITE THIS ARTICLE
Agbai EO, Eke CC, Nwanegwo CO, Anyaehie UB. Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats. J Phytopharmacol 2017;6(4):205-209.
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