The Journal of Phytopharmacology, 2014;3(1): 1-8 ; DOI:10.31254/phyto.2014.3101
Antinociceptive activity of various solvent extracts of Maerua angolensis DC stem bark in rodents
Iliya Hosea Azi1 , Boakye-Gyasi Eric2 , Adongo Wewura Donatus2 , Ampadu Felix Agyei2 , Woode Eric2
1. Department of Pharmacology, University of Jos, Jos, Nigeria
2. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
*Author to whom correspondence should be addressed.
Various parts of Maerua angolensis notably the leaves, roots and stem barks are used to reduce pain and also in the management of psychosis, epilepsy, and arthritis in traditional medicine. In this study, a preliminary test was performed to determine the most active plant part on the hydroethanolic extracts in the abdominal writhing test in mice. Subsequently, the stem bark, the most active plant part, was extracted with petroleum ether, ethyl acetate or hydroethanol to obtain three extracts which were tested for analgesic activity in the formalin test in rats. Animals were grouped into groups of 5 and the extracts were administered orally. Diclofenac and morphine were used as reference analgesic agents while normal saline was used for control. The leaf, root and stem bark extracts (30, 100 and 300 mg/kg) significantly (P
Maerua angolensis, Antinociception, Writhing, Formalin test.
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