The Journal of Phytopharmacology, 2014;3(2):139-148 ; DOI:10.31254/phyto.2014.3210
Immunomostimulant phytoconstituents from Mangifera indica L. bark oil
Chetan Savant1 , Anand Rao Kulkarni2 , Basheerahmed Abdulaziz Mannasaheb3 , Rahul Gajare2
1. Department of Pharmacology, Sarada Vilas College of Pharmacy, Mysore, Karnataka 570004, India
2. Department of Pharmacology, Soniya College of Pharmacy, Dharwad, Karnataka 580002, India
3. Department of Pharmacology3, East West College of Pharmacy, Bangalore, Karnataka 560091, India
*Author to whom correspondence should be addressed.
The present study was undertaken to isolate oil from Mangifera indica bark, Identification of various phytoconstituents and screening of immunostimulant activity in experimental animals. Methods: Immunostimulant activity was evaluated in rats as well as in mice by determining neutrophil adhesion to nylon threads and phagocytic index. Levamisole at a dose of 50 mg/kg, b.w was used as standard drug. Acute toxicity studies were carried out and the test drug doses were selected. Mangifera indica bark oil in the dose of 150 & 300 mg/kg b.w, p.o, were used. Results: Results indicate a significant increase in percent neutrophil adhesion (P
Haemagglutination antibody (HA) titer, Immunomodulatory, Mangifera indica, Neutrophil adhesion test, Phagocytic activity.
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