The Journal of Phytopharmacology, 2014;3(3):163-167 ;   DOI:10.31254/phyto.2014.3302

Research Article

Attenuation of depression on sub acute administration of Terminalia bellerica fruit in tail suspension test

Manohar V R¹ , Mohandas S Rai¹ , Ramya kateel¹ , Aishwarya aravind¹ , Deepthi shridar¹ , Floyd dsouza¹

Manohar V R,Mohandas S Rai,Ramya kateel,Aishwarya aravind,Deepthi shridar,Floyd dsouza

1. Department of Pharmacology, A.J. Institute of Medical Science & Research Centre, Mangalore575004, Karnataka, India

*Author to whom correspondence should be addressed.

Abstract

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Objective: The present study was undertaken to evaluate the sub acute antidepressant activity of aqueous extract of Terminalia Bellerica (AETB) fruit pulp in the tail suspension test (TST) as a model of depression in albino mice. Methods: Inbred adult male Swiss Albino mice weighing 25-30 g were divided into 5 groups of 6 animals in each. Group 1 (Control) received Gum acasia (10 ml/kg per oral), Group II received Standard drug Imipramine (10 mg/kg per oral), Group III, IV and V received the test drug AETB in doses of 9 mg/kg, 18 mg.kg and 36 mg/kg per oral respectively. All drugs were administered once daily for 10 days t. Duration of immobility was noted in the TST model. The results were analyzed using one way ANOVA with post hoc Dennett’s test. Results: The results showed significant reduction in the immobility with group IV (AETB given 18 mg/kg) and group V (AETB given 36 mg/kg) in comparison to the control group (1% Gum acacia) when subjected to TST, suggesting an antidepressant like activity. Conclusion: The results of the present study indicate the potential for use of AETB as an adjuvant in the treatment of depression.

Keywords

Tail suspension test, Terminalia bellerica, Imipramine

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