The Journal of Phytopharmacology, 2014;3(6):384-388 ; DOI:10.31254/phyto.2014.3602
Evaluation of synergistic antimicrobial activity of Gemifloxacin with Linum usitatissimum seed oil
Yogesh Joshi1 , Divya Juyal1 , Ruchika Garg1
1. Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand, India
*Author to whom correspondence should be addressed.
Gemifloxacin and Linseed (Linum usitatissimum L.) oil has individual in-vitro antimicrobial activity against a wide range of gram-negative and gram-positive microorganisms. To reduce dose dependent side effects and the development of drug-resistance by an antibiotic when used alone, in accordance with the maintenance of the effectiveness, the alternative approach nowadays is to go for combinations of antibiotic required for the treatment along with any other suitable agent for minimization of the above problems. This study involved an initial approach to evaluate the synergistic antimicrobial effects of gemifloxacin with linseed oil. The physicochemical properties of the oil determined were color, odor, specific gravity, acid value, iodine value and saponification value. Phytochemical analysis revealed that Linseed oil contains fats, flavonoids, glycosides, phenols and tannins. Combined antimicrobial effects of both gemifloxacin and linseed oil were then analyzed in different combinations using the microbial strains of Staphylococcus aureus, Bacillus subtillus, Escherichia coli and Shigella boyedi. From the results, it was concluded that linseed oil synergies the antimicrobial potential of gemifloxacin when used simultaneously in various combinations.
Gemifloxacin, Linseed oil, Antimicrobial activity, Synergistic.
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