The Journal of Phytopharmacology, 2015;4(6):276-281 ; DOI:10.31254/phyto.2015.4601
Neuro-protective role of seeds of Mucuna pruriens BEK and Mucuna monosperma DC in wistar albino rats
Ravi Mundugaru1 , Shridhara Bairy T2 , Desai Yogesh Hareshchandra3 , Ravikrishna S4 , Ravi Shankar B5
1. Research Officer; Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi-574118, India
2. Professor and Head; Department of Dravyaguna Vijnanam, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi574118, India
3. PG Scholar; Department of Dravyaguna Vijnanam, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi574118, India
4. Assistant Professor; Department of Dravyaguna Vijnanam, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi574118, India
5. Professor of Experimental Medicine and Director; Department of Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi-574118, India
*Author to whom correspondence should be addressed.
Mucuna pruriens Bek. and Mucuna monosperma DC. seeds were extensively used in Ayurveda for neuromuscular disorders. The objective of present study was to screen the neuroprotective activity of the test drugs in wistar albino rats. The cerebral ischemia was induced by bilateral common carotid artery occlusion for 60 minutes followed by reperfusion. At the end of the experiments under anaesthesia animals were sacrificed and brain was removed. Anti oxidant and histopathological examination was carried out of the brain tissue. Both test drugs have been shown considerable anti oxidant activity in comparison to BCCAO control group. Histopathological examination revealed there is a decreased cellularity and predominance of immature neurons in the granular layer was observed in hypothalamus in control rats while the test drug has shown normal cytoarchitecture. The sections of hippocampus from Mucuna monosperma DC group exhibited decreased cellularity of the granular layer and vacuolization was observed and Mucuna pruriens Bek treated group exhibited almost normal cytoarchitecture. In conclusion the test drugs possess moderate anti oxidant and cellular integrity maintaining potential in different brain regions and hence it supports its therapeutic claim in neuromuscular disorders.
Neuroprotective, Cerebral ischemia, Anti-oxidants, Hippocampus, Lipid peroxidation.
HOW TO CITE THIS ARTICLE
Hareshchandra DY, Mundugaru R, Bairy TS, Ravikrishna S, Shankar RB. Neuro-protective role of seeds of Mucuna pruriens BEK and Mucuna monosperma DC in wistar albino rats. The Journal of Phytopharmacology 2015;4(6):276-281.
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