The Journal of Phytopharmacology, 2015;4(6):287-294 ; DOI:10.31254/phyto.2015.4603
Protective effect of Andrographis paniculata on hyperglycemic mediated oxidative damage in renal tissues of diabetic rats
V. Sivakumar1 , S. Rajeshkumar1
1. PG & Research Department of Biochemistry, Adhiparasakthi College of Arts & Science, Kalavai, Tamil Nadu-632506, India
*Author to whom correspondence should be addressed.
The aim of this study is to evaluate the protective effect of ethanol extract of Andrographis paniculata (A. paniculata) on hyperglycemic mediated oxidative damage in the renal tissues of experimental diabetic rats and to determine the potential bioactive components of A. paniculata ethanol extract was scrutinized using GC-MS techniques. Diabetes was induced in rats by streptozotocin. Experimental period, the animal body weight, blood glucose, urea, serum proteins, cholesterol, antioxidant key enzymes and histological changes in kidneys were determined. The untreated diabetic and A. paniculata treated diabetic groups lost weight and consumed less quantity of food compared to the normal group. We noted decrease in blood glucose in the ethanol extract of A. paniculata treated diabetic group compared to normal and glibenclamide treated groups. The serum protein level was increase and cholesterol and urea levels were significantly (P
Andrographis paniculata, Diabetes mellitus, Streptozotocin, GC-MS techniques.
HOW TO CITE THIS ARTICLE
Sivakumar V, Rajeshkumar S. Protective effect of Andrographis paniculata on hyperglycemic mediated oxidative damage in renal tissues of diabetic rats. The Journal of Phytopharmacology 2015;4(6):287-294.
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