The Journal of Phytopharmacology, 2016;5(2):45-49 ; DOI:10.31254/phyto.2016.5202
Preclinical evaluation of antidiabetic activity of poly herbal plant extract in streptozotocin induced diabetic rats
P.P. Gupta1 , J. Haider2 , R.P. Yadav3 , U. Pal3
1. Professor, Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Patna, Bihar-801505, India
2. Associate Professor, Department of Pharmacology, BRD Medical College, Gorakhpur, Uttar Pradesh-273013, India
3. Department of Pharmacology, BRD Medical College, Gorakhpur, Uttar Pradesh-273013, India
*Author to whom correspondence should be addressed.
Objective: To study and compare the effect of Poly herbal plant extract (PHPE) with Glibenclamide (GL) on various parameters in Streptozotocin (STZ) induced diabetic rats. Methods: Diabetes was induced by combining High Fat-diet and injecting low dose Streptozotocin (35 mg/kg body wt.) to Sprague-dawley rats. Diabetic rats were treated with chloroform leaf extract of Azadirachta indica, aqueous leaf extract of Bougainvillea spectabilis and ethanolic seed extract of Trigonella foenum graecum combined in ratio of 1:2:3 respectively at dose of 600 mg/kg body weight by oral gavaging for 28 days. The results were compared with standard anti diabetic drug Glibenclamide given in dose of 500 µg/kg body weight. Results: Increase in body weight of both PHPE and GL treated diabetic rats was found to be statistically significant (p
Poly herbal plant extract, Glibenclamide, Fasting blood glucose, Total Cholesterol.
HOW TO CITE THIS ARTICLE
Gupta PP, Haider J, Yadav RP, Pal U. Preclinical evaluation of antidiabetic activity of poly herbal plant extract in streptozotocin induced diabetic rats. The Journal of Phytopharmacology 2016;5(2):45-49.
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