The Journal of Phytopharmacology, 2013;2(5): 21-27 ;   DOI:10.31254/phyto.2013.2504

Research Article

Endothelium-dependent and independent vasorelaxant effect of Terminalia superba (Combretaceae) on rat aorta

Dzeufiet Djomeni Paul Désiré¹ , Tadondjou Tchingo Cyrille D’Alex² , Bilanda Danielle Claude¹ , Aboubakar Oumarou BibiFarouck¹ , Kamtchouing Pierre¹ , Dimo Théophile¹

Dzeufiet Djomeni Paul Désiré,Tadondjou Tchingo Cyrille D’Alex,Bilanda Danielle Claude,Aboubakar Oumarou BibiFarouck,Kamtchouing Pierre,Dimo Théophile

1. Department of Animal Biology and Physiology, Faculty of Science, P.O Box 812 University of Yaounde I, Cameroon
2. Department of Animal Production, Faculty of Agriculture, P.O.Box 67 Dschang, University of Dschang, Cameroon

*Author to whom correspondence should be addressed.

Abstract

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Terminalia superba (Combretaceae) is a plant which is used in Cameroon for the treatment of many diseases including arterial hypertension. The vasorelaxant effect of the aqueous stem bark extract of T. superba was evaluated on the isolated aorta rings of the rat constricted with KCl (60 mM) or norepinephrine (10-5 M). Cumulative concentrations (20-100 µg/mL) of T. superba provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl. The maximum vasorelaxant activity of T. superba was 107.24 ± 7.01% on the intact aorta and 102.48 ± 19.09% on the denuded aorta contracted by norepinephrine. The evaluation of the effects of the aqueous extract of T. superba on the intact aorta precontracted by KCl showed a maximum relaxation of 68.43 ± 2.51% at a final concentration of 100µg/mL. The vasorelaxation induced by T. superba (100 µg/mL) on the intact aorta precontracted by norepinephrine was significantly reduced in the presence of Nw-nitro-L-arginine methyl ester (54.98 ± 6.0%, p

Keywords

T. superba, Aorta, Endothelium, Contraction, Vasorelaxation.

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