The Journal of Phytopharmacology, 2021;10(6):500-505 DOI:10.31254/phyto.2021.10612

Research Article

In vivo analgesic and healing activities of stem bark extracts of Gardenia ternifolia Schumach. & Thonn.

Sylla Tahiri^1,2 , Dongui Bini Kouamé²

Sylla Tahiri,Dongui Bini Kouamé

1. Laboratoire des Sciences et Technologies de l’Environnement (LSTE), UFR Environnement, Université Jean Lorougnon Guede (UJLOG), BP 150 Daloa, Côte d’Ivoire
2. Faculté de Pharmacie, Université de Montréal, C.P. 6128, succursale Centreville Montréal (Québec), Canada

*Author to whom correspondence should be addressed.

Received: 30th October, 2021 / Accepted: 16th December, 2021

Abstract

In Ivory Coast, medicinal plants have always been used traditionally to promote wounds repairs. They have great potential for wound healing by promoting the speed of wound healing with less pain, discomfort and patient healing. The plant Gardenia ternifolia belongs to the family Rubiaceae. The macerated stem bark or the paste obtained is also used against bites snake, sexual impotence, hemorrhoids, healing wound, injury, and tooth decay. Gardenia ternifolia was extracted in aqueous and ethanol to evaluate acetic acid-induced writhing test to detect the peripheral analgesic activity of the extracts in mice. AEGT and EEGT showed reduced number of writhes which are significant compared to control (Acetaminophen). The results obtained support the use of Gardenia ternifolia in painful conditions acting peripherally. The healing activity of Gardenia ternifolia was also evaluated in the second part of the research. AEGT_50% and EEGT_50% ointments treated group showed a significant reduction in the wound breaking strength in incision type of wound model and significant increase in epithelization period and reduction in percentage of wound area in excision type of wound model as compared to control group treated with simple ointment.