The Journal of Phytopharmacology, 2020;9(4):224-229 DOI:10.31254/phyto.2020.9402
Antidiabetic effects of partitioned methanol extract of Boswellia dalzielii (Frankincense tree) on rats
James Yakubu1 , Umar Tanko Mamza1 , Victor Musa Balami1 , Asinamai Ndai Medugu1 , Fanna Inna Abdulrahman1 , Olufunke Adebola Sodipo2
1. Department of Pure and Applied Chemistry, Faculty of Science, University of Maiduguri, Maiduguri, Borno State, Nigeria
2. Department of Clinical Pharmacology and Therapeutics, College of Medical Science, University of Maiduguri, Maiduguri, Borno State, Nigeria
*Author to whom correspondence should be addressed.
Received: 17th May, 2020 / Accepted: 7th June, 2020
Medicinal plants have been the major source of bioactive phytochemicals employed for the treatment and management of disease since time immemorial. The present study was aimed at investigating the antidiabetic potentials of various partitioned portions of crude methanol extract of Boswellia dalzielii in alloxan-induced diabetic rats. Fresh leaf of Boswellia dalzielii was air-dried, pulverized and extracted using cold maceration method with 85% methanol and concentrated to dryness. The crude methanol extract was partitioned using n-hexane, chloroform, ethylacetate and n-butanol to afford portions encoded BMENH, BMECM, BMEEA, BMENB respectively, and were screened for phytochemicals. The portions were evaluated for their anti-diabetic effects on alloxan-induced rats. The phytochemical studies of the crude methanol leaf, stem and root bark extracts revealed the presence alkaloids, cardiac glycoside, flavonoids, saponins, tannins and terpenoids. The partitioned crude methanol leaf extract yielded 14.12 % ( w/w) n-hexane, 6.85 % (w/w) chloroform, 4.18% (w/w) ethyl acetate and 36.40 % (w/w) n-butanol extracts respectively. Antidiabetic activity of fractions BMEH, BMEC, BMEE at doses of 200 and 400 mg/kg bd wt. produced significant (p
Diabetes, anti-diabetes, phytochemicals, alloxan, Boswellia dalzielii.
HOW TO CITE THIS ARTICLE
Yakubu J, Mamza UT, Balami VM, Medugu AN, Abdulrahman FI, Sodipo OA. Antidiabetic effects of partitioned methanol extract of Boswellia dalzielii (Frankincense tree) on rats. J Phytopharmacol 2020 ; 9 ( 4):224 -229 .
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