ISSN: 2320-480X
Manuscript Submission

The Journal of Phytopharmacology, 2020;9(4):252-257 DOI:10.31254/phyto.2020.9407

Research Article

Antiinflammatory and antioxidant evaluation of Maytenus senegalensis hydroalcoholic roots extract fractions in allergic asthma

Pascaline Kindji Kpoyizoun1 , Kossi Metowogo1 , Yendoubé T Kantati1 , Afiwa Missebukpo1 , Tchin Dare2 , Povi Lawson-Evi1 , Kwashie Eklu-Gadegbeku1 , Kodjo A Aklikokou1 , Elizabeth U Egu1

1. Department of Animal Physiology: Laboratory of Physiology and Pharmacology, Research Unit: Pathophysiology, Bioactive Substances and Safety. Faculty of Sciences, University of Lomé, Togo
2. Department of Pathological Anatomy and Cytology. Faculty of Health sciences, University of Lomé, Togo

*Author to whom correspondence should be addressed.

Received: 5th June, 2020 / Accepted: 27th July, 2020

Abstract


The present work aims to evaluate the antiinflammatory and antioxidant activities of the Maytenus senegalensis (Lam.) roots hydroethanolic extract and to determine its active fraction. The total extract is fractioned in cold alcohol 75%. Phytochemical studies and in vitro antioxidant test are performed on the extract and obtained fractions. During 28 days, mice were sensitized and challenged with OVA to induce allergic airway inflammation. the anti-inflammatory effect of the plant extract and its fractions is assessed by differential white blood cell counts and histopathological examinations. Them antioxidant effect is evaluated in vivo by MDA and glutathione dosage. Qualitative and quantitative phytochemical tests showed that the extract and its fractions contain phenolics compounds. In vitro, both extract and its fractions expressed antioxidant activities. Treatment with M. senegalensis extract and its fractions significantly decreased inflammatory cells number in BALF, reduced MDA concentration and enhanced glutathione level (p

Keywords


Allergic asthma, Maytenus senegalensis, Antiinflammatory, Antioxidant.

HOW TO CITE THIS ARTICLE

Kpoyizoun PK, Metowogo K, Kantati YT, Missebukpo A, Dare T, LawsonEvi P, et al. Antiinflammatory and antioxidant evaluation of Maytenus senegalensis hydroalcoholic roots extract fractions in allergic asthma. J Phytopharmacol 2020; 9(4):252-257.

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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) license. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (http://creativecommons.org/licenses/by/4.0/).

Copyright

Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0.

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