The Journal of Phytopharmacology, 2019;8(3):91-95 DOI:10.31254/phyto.2019.8302

Research Article

Endothelium-dependent and independent effect of Guibourtia tessmannii (Caesalpiniaceae) on vascular contractility of rat

Koumba Madingou Noreen Orianna^1,2 , Aworet Samseny Reine Raissa¹ , Souza Alain³ , Sababenedyo Traore Alfred²

Koumba Madingou Noreen Orianna,Aworet Samseny Reine Raissa,Souza Alain,Sababenedyo Traore Alfred

1. Laboratory of Pharmacology and Toxicology, Pharmacopoeia and Traditional Medicines Insti-tute, BP 1935 Libreville, Gabon.
2. Research Center in Biological, Food and Nutritional Sciences, University of Ouagadougou, 03 BP 7129 Ouagadougou, Burkina Faso.
3. Department of Biology, Faculty of Sciences, University of Sciences and Technique of Ma-suku (USTM), BP 941 Franceville, Gabon

*Author to whom correspondence should be addressed.

Received: 4th June, 2019 / Accepted: 8th May, 2019

Abstract

The stem barks of Guibourtia tessmannii (Caesalpiniaceae) are used in traditional Gabonese medicine as antihypertensive remedies. In the present study, we investigated vasorelaxant properties effect of aqueous extract from G. tessmannii and fuller understanding these mechanisms of action in vitro. The activity of Guibourtia tessmannii was evaluated on isolated aorta rings of rat constricted with KCl (80 mM) and norepinephrine (10-4 M). Cumulative concentrations (1 mg/mL - 100 mg/ml) of G. tessmannii provoked a dose-dependent relaxation of the thoracic aorta precontracted by norepinephrine or KCl (95.69 ± 0.6% and 91.34 ± 4.90%, respectively). The vasorelaxant effect induced by G. tessmannii on the aorta precontracted by KCl was significant decreased in presence of N?-nitro-L-arginine methyl ester (11.30 ± 4.3 %, p