The Journal of Phytopharmacology, 2019;8(6):279-281 DOI:10.31254/phyto.2019.8601

Research Article

Hypolipidemic effect of ethanolic extracts of Adansonia digitata fruit pulp on hyperlipidemic albino rats

Nafisa A. A. Abdelgadir¹ , Abdelkareem MM Salih² , Saad MH Ayoub¹

Nafisa A. A. Abdelgadir,Abdelkareem MM Salih,Saad MH Ayoub

1. Department of Pharmacognosy, Faculty of Pharmacy, Al-Neelain University, Khartoum, Sudan
2. Department of Pharmacology, Faculty of Pharmacy, Al-Neelain University, Khartoum, Sudan

*Author to whom correspondence should be addressed.

Received: 22nd November, 2019 / Accepted: 7th December, 2019

Abstract

Recently hyperlipidemia has become an overwhelming disorder, as food diminished for fibers rich in fats and carbohydrates. Adansonia digitata is an iconic tree of Africa, noteworthy has a considerable number of benefits for health and the environment. The present study was carried out to evaluate hypolipidemic properties of 96% maceration and Soxhlet ethanolic extracts of A. digitata fruit pulp. Serum lipid parameters; (cholesterol, triglyceride, high density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were investigated. Twenty-four hyperlipidemic Wister albino rats (males) weighing 160-240g were divided randomly into four groups, six for each. All sub groups were orally administered extracts once daily for twenty-eight days by two doses (200 & 400) mg/kg.bwt from each maceration and Soxhlet extracts. Blood samples were investigated at 14 and 28 days. Both extracts significantly lowered serum cholesterol, triglycerides, and low-density lipoprotein, not affecting high density lipoprotein. Soxhlet extraction was more efficient, degree of effectiveness depends more on concentration and continuation of treatment. Phytochemical screening revealed presence of all constituents except anthracenes.