The Journal of Phytopharmacology, 2018;7(1):79-83 DOI:10.31254/phyto.2018.7116

Research Article

Cuminum cyminum methanolic extract prevents oxidative modification of low density lipoproteins: Preliminary evidence on its anti-atherosclerotic potential

Ranjitsinh Devkar¹ , Kiran Lagu² , Jaymesh Thadani¹ , Kavita Shirsath¹

Ranjitsinh Devkar,Kiran Lagu,Jaymesh Thadani,Kavita Shirsath

1. Division of Phytotherapeutics and Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat–390002, India
2. Formulation Development, Alvogen, 10B, Bloomfield Avenue, Pine Brook, NJ, USA

*Author to whom correspondence should be addressed.

Received: 30th December, 2017 / Accepted: 16th February, 2018

Abstract

The significance of oxidative modification of LDL in the pathogenesis of atherosclerosis and the lack of efficient treatment intervention has led researchers to develop an effective therapy based on natural antioxidants. The present study provides preliminary evidence in support of the anti-atherosclerotic potential of methanolic extract of Cuminum cyminum L. (CC). We found that CC inhibited Cu2+ -mediated LDL oxidation as demonstrated by the ex vivo LDL oxidation kinetic study, the LDL oxidation products (malondialdehyde, lipid hydroperoxide and protein carbonyl), and ApoB fragmentation assay. It can be concluded that, CC efficiently alleviates experimentally induced oxidative changes and modifications of LDL. Since oxidative changes in LDL are prerequisite to onset of atherogenic changes, this study provides preliminary evidence on anti-atherosclerotic potential of CC.