The Journal of Phytopharmacology, 2018;7(2):185-190 DOI:10.31254/phyto.2018.7214
Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice
Oghale Ovuakporie-Uvo1 , MacDonald Idu1 , Philip Obarisiagbon2 , Callistus Abode3
1. Department of Plant Biology and Biotechnology, University of Benin, PMB 1154, Benin City, Edo State, Nigeria
2. Department of Pharmacology and Toxicology, University of Benin, 300001 Benin City, Nigeria
3. Department of Science Laboratory Technology, University of Benin, Benin City, Nigeria
*Author to whom correspondence should be addressed.
Received: 14th March, 2018 / Accepted: 9th April, 2018
Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-?, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p
Analgesic, Inflammation, Gene Expression, Desplatsia dewevrei.
HOW TO CITE THIS ARTICLE
Uvo OO, Idu MD, Obarisiagbon P, Abode C. Analgesic, Pro and AntiInflammatory Activities of Desplatsia Dewevrei; Cytokine Gene Expression using Wistar Rats and Mice. J Phytopharmacol 2018; 7(2):185- 190.
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