The Journal of Phytopharmacology, 2017;6(6):343-348 DOI:10.31254/phyto.2017.6607

Review Article

TILIROSIDE: Biosynthesis, Bioactivity and Structure Activity Relationship (SAR) - A Review

Lokadi Pierre Luhata^1,2 , Wembi Gaston Luhata³

Lokadi Pierre Luhata,Wembi Gaston Luhata

1. Faculty of Sciences and Technologies University Loyola du Congo (ULC), 3724, Kinshasa, The Democratic Republic of Congo (DRC).
2. Department of Chemistry, University of Zambia, 32379, Lusaka, Zambia
3. Bralima –Kinshasa; Bralima: 1 Av du drapeau, B.P.7246 Kinshasa RDC

*Author to whom correspondence should be addressed.

Received: 27th October, 2017 / Accepted: 10th December, 2017

Abstract

Tilirosides (TLD) are glycosidic flavonoids (GFD) from originating in plants that exhibit a range of bioactivities of great interest for healthcare: antioxidant, anti-microbial, antifungal, anti-diabetic and antihyperlipedemic, antiviral and cytotoxic, anti–inflammatory, anti-rheumatism, inhibition of neuroinflammation and acute inflammation and hepatoprotective activities. TLD are biosynthesized in plants in three main steps. First, the synthesis of the aglycone (a flavonoid) occurs, which follows the shikimate pathway with cinnamoylCoA as a starter unit. Second, there is the glucosylation of the aglycone using Uridine diphosphosugar (UDPglucose) as the agent for glycosylation. Finally, the coumaroyl part is added. The Structure Activity Relationship of TLD reveals that the addition of the para coumaric acid moiety considerably modifies their bioactivity.