The Journal of Phytopharmacology, 2022;11(1):24-31 DOI:10.31254/phyto.2022.11105

Research Article

Diuretic and antihypertensive activity of the aqueous extract of Haematostaphis barteri stem bark in adrenaline-induced hypertensive Wistar Rats

Fidele Ntchapda¹ , Ernest Rodrigue Talla¹ , Hamadjida Adjia² , Christian Bonabe¹ , Angele Bello Kopodjing¹ , David Miaffo³ , Paul F Seke Etet⁴

Fidele Ntchapda,Ernest Rodrigue Talla,Hamadjida Adjia,Christian Bonabe,Angele Bello Kopodjing,David Miaffo,Paul F Seke Etet

1. Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Cameroon
2. Department of Biology, Higher Teachers’ Training College, University of Ngaoundere, Cameroon
3. Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, Cameroon
4. Department of Physiological Sciences and Biochemistry, FMBS, University of Ngaoundere, Cameroon

*Author to whom correspondence should be addressed.

Received: 26th December, 2021 / Accepted: 22nd January, 2022

Abstract

Decoctions of the stem bark of the medicinal plant Haematostaphis barteri are used in African traditional medicine to treat hypertension. We assessed the diuretic and antihypertensive activities of H. barteri stem bark in Wistar rats. Changes on urine volume and electrolyte elimination induced by acute and subacute treatment of Wistar rats with aqueous extract of the stem bark of H. barteri (150, 200 and 250 mg/kg, per os). Then, the effects of a week of daily treatments with the extract on indicators of disease progression were assessed in adrenaline-induced hypertensive rats. In a dose-dependent fashion, the extract significantly reduced the urination latency (from 60±2.5 sec in vehicle group to 30±3 sec with dose 250 mg/kg), and increased the urine and electrolyte elimination (more than 2-fold, (P