The Journal of Phytopharmacology, 2022;11(2):64-74 DOI:10.31254/phyto.2022.11203
In vitro antibacterial activity of biologically synthesised silver nanoparticles using Terminalia avicenoides extracts against multidrug resistant Staphylococcus aureus strains
Bobai M1 , Danjuma L2 , Sani N.M2
1. Department of Microbiology, Faculty of Science, Kaduna State University, Kaduna, Nigeria
2. Department of Microbiology and Biotechnology, Federal University Dutse, Jigawa, Nigeria
*Author to whom correspondence should be addressed.
Received: 14th January, 2022 / Accepted: 24th February, 2022
Antimicrobial resistance is currently one of the risen concerns to global healthcare in the 21st century. The search for new phytochemicals that could be developed as drugs for treatment of infectious diseases consequently increased with medicinal plants extracts derived nanoparticles receiving greater attention. This study was carried out to determine invitro antimicrobial activity of biologically synthesized silver nanoparticles using Terminalia avicenoides extracts against multidrug resistant Staphylococcus aureus strains isolated from wound infections. Isolation and characterization of Staphylococcus aureus was carried out using standard phenotypic and genotypic methods. Antimicrobial activity of selected antibiotics, Terminalia avicenoides extracts and biologically synthesized silver nanoparticles against multidrug resistant Staphylococcus aureus was carried out using standard procedures. The results of the susceptibility profile showed Staphylococcus aureus isolates resistant to 8.18% to 100% conventional antibiotics used, but 100% sensitive to imipenem. Phytochemical analysis of the extracts revealed the presence of tannins, alkaloids, flavonoids, cardiac glycoside, phenols, saponins and terpenoids. The antimicrobial activity of the biologically synthesized silver nanoparticles against multidrug resistant Staphylococcus aureus ranged from 28.25±1.90–30.65±2.21 mm and showed significant difference (p
Staphylococcus aureus, Multidrug Resistance, Nanoparticles, Wound, Antimicrobial, Terminalia avicenoides.
HOW TO CITE THIS ARTICLE
Bobai M, Danjuma L, Sani NM. In vitro antibacterial activity of biologically synthesised silver nanoparticles using Terminalia avicenoides extracts against multidrug resistant Staphylococcus aureus strains. J Phytopharmacol 2022; 11(2):64- 74. doi: 10.31254/phyto.2022.11203
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