The Journal of Phytopharmacology, 2014;3(3):176-179 DOI:10.31254/phyto.2014.3304

Research Article

Effect of two sesquiterpene lactones from Capparis decidua (Forsk.) on arachidonic acid and adenosine diphosphate-induced platelets aggregation

Mona S. Mohammed¹ , Hassan S. Khalid² , A. K. Muddathir¹ , Kamal .E.H. El Tahir³ , Bashier Osman⁴ , Wadah J.A. Osman¹ , Omer Basudan⁵

Mona S. Mohammed,Hassan S. Khalid,A. K. Muddathir,Kamal .E.H. El Tahir,Bashier Osman,Wadah J.A. Osman,Omer Basudan

1. Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Sudan
2. Medicinal and Aromatic Plants Research Institute, National Council for Research, Khartoum, Sudan
3. Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
4. Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Sudan
5. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia

*Author to whom correspondence should be addressed.

Abstract

Variable responses among individual patients, in addition to adverse effects are the main challenges facing most commonly used antiplatelet therapies like aspirin for example. Therefore, there is a need to seek naturally occurring, plant-derived substances which show minimal side effects. Capparis decidua is an indigenous shrub widely distributed in desert and semi-desert area of northern and central Sudan. Phytochemical investigation of aerial parts of Capparis decidua resulted in isolation of two new sesquiterpine lactones: MW-6 ( germacr-3?ol-7,9-dien-6,14-olide-15-oic acid) and MW-11 (Germacr-3?-ol-12-ene-6,14-olide-15-oic acid) along with several known compounds. The two compounds have shown potent antiplatelets activity evaluated by using of guinea-pig platelets rich plasma mode. These compounds may provide a chemical moiety for more potent analogues.