The Journal of Phytopharmacology, 2015;4(3):139-142 DOI:10.31254/phyto.2015.4302

Research Article

Impact of Solanum surettense on membrane bound Na+/K+ ATPase and in vivo anti oxidants activity on isoproterenol induced myocardial injury in rats

Chitikela P Pullaiah¹ , S. Dhanunjaya¹ , GV. Narasimha Kumars¹ , D. Pichaiah¹ , M. Venkateswarlu¹ , Ranganayakulu D¹

Chitikela P Pullaiah,S. Dhanunjaya,GV. Narasimha Kumars,D. Pichaiah,M. Venkateswarlu,Ranganayakulu D

1. Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tirupati-517503, Andhra Pradesh, India

*Author to whom correspondence should be addressed.

Abstract

The present study was designed to evaluate the cardio protective potential of ethanolic extract of Solanum surettense a warm-climate annual herb, on isoproterenol-induced Myocardial Infarction (MI) in rats. Five groups of albino rats, each comprising six animals, were selected for this study. Group I served as a control, Group II rats were given isoproterenol (ISO) (85mg/kg subcutaneously), and Group III rats were treated with propranolol 10mg/kg as standard treatment. Groups IV and V rats were given ESS (200 mg/kg and 400 mg/kg, respectively) along with isoproterenol (85mg/kg). At end of the study cardiac biomarkers like CK-MB and LDH were estimated to accesses cardio protection. The protective effect of heart is also accessed by estimation of membrane bound Na+ /K+ATPase and tissue antioxidant enzymes like SOD, Catalase and GSH. ESS pre treated animals in various doses significantly decreased the levels of CK-MB and LDH when compared with ISO treated animal. The dose of 400 mg/kg has shown significant protection than 200 mg/kg of ESS i.e. dose dependent cardio protection. The study confirms the cardio protective potential of ethanolic extract of Solanum surettense against isoproterenol-induced biochemical alterations in rats.