The Journal of Phytopharmacology, 2015;4(5):268-275 DOI:10.31254/phyto.2015.4506

Research Article

Gastric and duodenal antiulcer effects of aqueous bark extract of Dialium guineense Wild. (Fabaceae) and the possible mechanisms in laboratory models

Esther Oluwatoyin Agbaje¹ , Yewa Peace Doe¹

Esther Oluwatoyin Agbaje,Yewa Peace Doe

1. Department of Pharmacology, College of Medicine, University of Lagos, University Rd, Lagos, P.M.B. 12003, Nigeria

*Author to whom correspondence should be addressed.

Abstract

The plant Dialium guineense (DAG) has been claimed by local users, to be effective in the treatment of peptic ulcers, especially, when taken as an aqueous decoction. The present study assessed the antiulcer activity of the plant, as well as explored the possible mechanisms of action of the herbal drug, aside identifying some of the various phytoconstituents, which could be responsible for its antiulcer activity. Different ulcerogens (ethanol 99.9 %, indomethacin 50 mg/kg, cysteamine 400 mg/kg, glacial acetic acid) and the pylorus ligation-induced ulcers were used to induce acute and chronic ulcers, with doses of 100, 300 and 750 mg/kg DAG and the standard drugs relative to each model, while assessing drug activity through ulcer scoring and comparing it with both the negative and positive controls. The extract, which has an LD50 of 1584.89 mg/kg when administered intraperitoneally, recorded a significant (p