The Journal of Phytopharmacology, 2013;2(4): 13-21 DOI:10.31254/phyto.2013.2403

Research Article

Biochemical and histological study of traditional plant: Dodonaea viscosa Linn extracts in diabetic rats

M. Sandhya Rani¹ , P. Venkatesh² , Rao. S. Pippalla³ , G. Krishna Mohan¹

M. Sandhya Rani,P. Venkatesh,Rao. S. Pippalla,G. Krishna Mohan

1. Department of Pharmacognosy and Phytochemistry, Centre for Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
3. Department of Pharmacy, TP College of Pharmacy, Kakatiya University, Warangal, Andhrapradesh, India

*Author to whom correspondence should be addressed.

Abstract

Aim of this study was to evaluate the individual biochemical changes of leaf extracts of Dodonaea viscose-A traditional plant in alloxan induced diabetic rats. Methanol and chloroform extract of Dodonaea viscosa were obtained by cold maceration and were administered to alloxan induced diabetic albino rats. Parameters including blood glucose, triglycerides, cholesterol, protein, urea, creatinine, SGPT, SGOT were checked using standard test kits and methods after administration of extracts. Histological changes in pancreas and liver of the animal were also examined. Extract treated groups shown reduction in blood glucose level to normal. Increased levels of all other biochemical parameters like SGPT, SGOT, Triglycerides, Cholesterol, Protein, Creatinine and Urea with alloxan treatment have been significantly reduced in extract treated groups. Histological changes supported this claim. Finally, the implications of results after administration of the extracts show their potential use in management of diabetes.