The Journal of Phytopharmacology 2023; 12(4):272-275 DOI:10.31254/phyto.2023.12410
Determination of lipid lowering properties of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats
Pinkey Rawal1 , Ramesh C2 , Sowmya B A3 , Ranjitha CJ3
1. Assistant Professor & HOD, Department of Pharmaceutical Chemistry, East West College of Pharmacy, Bangalore-560091, India
2. Professor & HOD, Department of Pharmacology, East West College of Pharmacy, Bangalore-560091, India
3. Assistant Professor, Department of Pharmacology, East West College of Pharmacy, Bangalore-560091, India
*Author to whom correspondence should be addressed.
Received: 8th July, 2023 / Accepted: 21st August, 2023 / Published : 31st August, 2023
Objectives: The present study was performed to determine hypolipidemic potentials of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats. Methods: Defatted powdered drug of ariel parts of Tephrosia villosa was subjected to methanol extraction using soxhlet extractor. The high fat diet induced hyperlipidemia in rat model was used for the present investigation in which all experimental rats were ingested with high fat diet (HFD) for entire period of study and were also administered with methanol extract for 21 days. Blood samples were collected from all the animals on day 21st after one hour of administration of the drugs and serum lipid profile (total cholesterol, triglycerides, HDL, LDL and IDL) was estimated. All animals were sacrificed after the blood sampling and liver samples were collected. Results: The rats of therapeutic groups ingested with extract of Tephrosia villosa and standard drug atorvastatin have shown significant reduction in serum cholesterol, serum triglycerides, LDL and increase in HDL indicating its ability to attenuate the effects of high fat diet. Conclusion: The methanol extract of Tephrosia villosa shown significant hypolipidemic effects against high fat diet induced hyperlipidemia wistar rats by inhibiting cholesterol synthesis in liver.
Hyperlipidemia, Tephrosia villosa, Lipid profile, High Fat Diet
HOW TO CITE THIS ARTICLE
Rawal P, Ramesh C, Sowmya BA, Ranjitha CJ. Determination of lipid lowering properties of methanol extract of Tephrosia villosa against high fat diet induced hyperlipidemia in wistar rats. J Phytopharmacol 2023; 12(4):272-275. doi: 10.31254/phyto.2023.12410
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